- Artesunate Tablet is developed for killing the erythrocytic stage of plasmodium asexual form. It is effective to malaria caused by chloroquine resistant strain of plasmodium falciparum. ment of Toxoplasmosis
- Treatment of Acute Malaria
- Chemoprophylaxis of Malaria
Orally: treatment of uncomplicated falciparum malaria in areas where there is evidence of chloroquine, pyrimethamine/sulfadoxine, mefloquine and quinine resistance. It should always be administered together with mefloquine in full therapeutic dose.
Other Indications & Uses
CDC: 2.4 mg/kg IV x4 doses over 3 days
WHO: 2.4 mg/kg IV/IM at 0, 12 hours, 24 hours, THEN qDay
PO (not available in US): 4 mg/kg qDay x3 days (with mefloquine)
Drug-induced fever can occur.
Neurotoxicity has been observed in animal studies but not in humans. In view of the uncertainty about toxic effects, caution should be exercised when more than one 3-day treatment is given.
Cardiotoxicity has been observed following administration of high doses.
- Doses for the treatment: Oral, 50 mg, twice per day for 5 days successively. Double doses on the first day.
- Doses for Prevention of Malaria: Oral, 100mg once a week, from one week
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