Below are some of the details of Tamoxifen(generic)
Tamoxifen is an antagonist of the estrogen receptor in breast tissue. It has been the standard endocrine (anti-estrogen) therapy for hormone-positive early breast cancer, although aromatase inhibitors have been proposed for postmenopausal women.
Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.
Tamoxifen was discovered by ICI Pharmaceuticals (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name “tamoxifen.”
What are the drugs that interact with Tamoxifen Citrate?
Drugs that interact with Tamoxifen Citrate include the following:
This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.
What are the side effects of Tamoxifen Citrate?
The following are the most common side effects of Tamoxifen Citrate:
- Fluid retention
- Hot flushes
- Missed periods
- Pain and swelling of the limbs
The following are the severe side effects and you may require immediate medical attention:
- Blistering and peeling of the skin
- Blurry vision
- Change in vaginal discharge
- Increased liver enzymes
- Skin rash
- Vaginal bleeding
- Yellow eyes or skin
This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.
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