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What is Isentress?

Isentress (raltegravir) belonges to a group of antiretroviral drugs that prevent human immunodeficiency virus (HIV) from multiplying in your body.

Isentress is a HIV medicaation used to treat HIV, the virus that can cause the acquired immunodeficiency syndrome (AIDS). Isentress is not a cure for HIV or AIDS.

Raltegravir is for use in adults and children who weigh at least 4.4 pounds (2 kilograms).

 

How to use Isentress Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isentress 400mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Before taking this medicine

You should not use Isentress if you are allergic to raltegravir.

To make sure Isentress is safe for you, tell your doctor if you have ever had:

  • a muscle disorder;
  • kidney disease (or if you are on dialysis);
  • liver disease; or
  • mental illness or depression.

Isentress chewable tablets contain phenylalanine. Talk to your doctor before using this form of raltegravir if you have phenylketonuria (PKU).

It is not known whether Isentress will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Isentress on the baby.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

What are the side effects of Isentress?

The most commonly reported side effects when taking Isentress tablets 400mg include: nausea, vomiting, headaches, tiredness, inflammation of the nasal passages and throat, trouble sleeping, upper respiratory tract infection, cough, fever, bronchitis, back pain and depression.  A more serious but less common side effect is a condition is a severe skin reaction including Stevens-Johnson syndrome and toxic epidermal necrolysis.

When should Isentress not be used?

You should not use Isentress tablets 400mg if you:

  • are allergic to raltegravir or any ingredients in Isentress
  • are pregnant or are breastfeeding
  • are taking medicines that interact with Isentress, including antacids containing aluminium and/or magnesium, the anti-infective rifampicin

How should Isentress be taken?

You should take your Isentress tablets 400mg with a glass of water twice daily, with or without food and in combination with other antiretroviral drugs that have been prescribed.  You should continue to take your Isentress tablets 400mg for as long as recommended by your doctor, and you will be monitored carefully to ensure that you do not develop any serious side effects, in which case your doctor will probably recommend that you stop taking your Isentress tablets 400mg.

 

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