Triomune is a fixed dose combination treatment for Human Immunodeficiency Virus (HIV) infection in adults. Triomune tablets are used to treat HIV patients who have already been treated with other HIV medications and have responded well to each of the drugs in the combination; and are also able to tolerate each of these medications, at the recommended doses without requiring a dose adjustment due to low weight. HIV impairs the immune system by attacking specific immune cells called CD4+ cells that are involved in fighting infection, which can lead to opportunistic life-threatening infection (infections that would not normally be harmful); also if too many CD4+ cells are destroyed this can result in acquired immune deficiency syndrome (AIDS). Triomune 40MG tablets prevent or slow down the ability of HIV to replicate and spread, which keeps the amount of virus (viral load) down to a low level; allowing the numbers of CD4+ cells to increase, so that the immune system can recover, reducing the risk of disease progression. Triple drug therapy with Triomune 40 makes it easier to take the medications regularly, which helps improve compliance and helps prevent resistance of HIV to individual drugs.
Triomune-40 is a tablet composition of Stavudine 40mg, Lamivudine 150mg and Nevirapine 200mg. Lamivudine and Stavudine belongs to a class of medication called nucleoside reverse transcriptase inhibitors. Lamivudine decreases the amount of virus (HIV and hepatitis) in the blood. Stavudine works by inhibiting multiplication of viruses thus decreasing their levels in the infected patient. Nevirapine belongs to a class of anti-HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Triomune-40 tablet is a combination therapy for people with Human Immunodeficiency Virus (HIV) infection.
What are the side effects of Triomune?
The most commonly reported side effects when taking Triomune tablets are related to the individual drugs in the fixed dose combination tablets and include:
- Stavudine: severe peripheral neuropathy, which is dose related and occurs more frequently in patients with advanced HIV infection or who have previously experienced peripheral neuropathy.
- Lamivudine: nausea, vomiting, headaches, abdominal pain and discomfort, peripheral neuropathy, arthralgias, myalgias, skin rash, pancreatitis
- Nevirapine: development of rash and liver toxicity; both could be potentially life threatening if severe and needs careful monitoring
A more serious but less common side effect is a condition called lactic acidosis which is excess lactic acid in the blood due to liver damage, which may cause pancreatitis, liver failure, or renal failure
What are the health risks when taking Triomune?
Lactic acidosis is a rare but potentially fatal condition that has been reported when taking an antiretroviral nucleoside analogue, such as in Triomune tablets. It is caused by a build up of excess of lactic acid in the blood due to liver damage, which is usually associated with hepatomegaly (liver enlargement) with steatosis (build up of fat in the liver) and may cause pancreatitis, liver failure, or renal failure. Symptoms begin within a few months of treatment and include: nausea, vomiting and abdominal pain, difficulty breathing, loss of appetite, weight loss, motor weakness.
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