Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aprecap 125mg Capsule used may be taken with or without food, but it is better to take it at a fixed time.
How does Aprecap work?
Aprecap 125mg Capsule side effects contain aprepitant, a selective high-affinity antagonist of the substance P neurokinin 1 (NK1) receptor. Substance P belongs to a group of neurokinins (NKs), which are small neurotransmitters, or chemical messengers that transmit signals to and from the neurones (brain cells), and it has an important role triggering emesis (vomiting). The vomiting reflex is triggered by stimulation of vomiting centre in the brain, which is a complex area of neuronal networks, by one of several afferent nerve pathways (nerve signals carried to the brain). This can activate vomiting via one of several neurotransmitter receptors. Aprecap 125mg Capsule reviews chemoreceptor trigger zone (CTZ) is one of these afferent nerve pathways and is located in the area postrema of the brain, which is not protected by the blood-brain barrier and therefore, is readily accessible to circulating toxins and drugs. The vomiting centre contains high concentrations of substance P and its receptor neurokinin 1 (NK1), in addition to other receptors for neurotransmitters like serotonin (5HT) and dopamine. Substance P is released by nerve cells in response to stressful stimuli such as toxins and the biological effects of substance P, including emesis, are triggered by the binding of substance P to its NK1 receptor. Aprepitant in Aprecap 125mg Capsule competitively binds to NK1 receptors, which blocks the binding of substance P to its receptor and this prevents signal transduction that induces the vomiting reflex. Chemotherapy can also cause the release of serotonin (5HT) from the cells of the small intestine, which stimulates 5HT3 receptors that are found on the vagal nerves in the intestines, sending signals to the vomiting centre in the brain, and this is another afferent pathway that induces the vomiting reflex. Standard therapy for preventing nausea and vomiting following chemotherapy includes a serotonin receptor antagonist, as well as an anti-inflammatory corticosteroid. Aprepitant in Aprecap capsules combined with standard therapy augments the antiemetic effects to improve protection against emetogenic chemotherapy1, 2.
Aprecap Capsule – Side-effects
The following is a list of possible side-effects that may occur from all constituting ingredients of Aprecap 125mg Capsule side effects
. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
- Aprecap Capsule may also cause side-effects not listed here.
If you miss a dose of Aprecap 125mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
How should Aprecap be stored?
You should store your Aprecap 125mg Capsule stored below 25°C in a cool dry place.
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